Age Associated Fluoride Induced Ultra Structural and Biochemical Changes in Rat Brain

Conclusion In the present study, aged rats were more prone to fluoride induced lipid peroxidation, increased lipofuscinogenesis and reduced antioxidant level. The biochemical and ultrastrural changes observed in fluoride treated young rats were comparable to those of untreated old control rats. Therefore, fluoride may play a role in the premature aging of animals. However, further in depth studies in other models are required to unravel the role of fluoride in the pathophysiology of aging.


Isn't there enough studies done already?