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UK Against Fluoridation

Friday, May 18, 2018

Effect of fluoride on major organs with the different time of exposure in rats

  • Thanusha Perera,
  • Shirani RanasingheEmail author,
  • Neil Alles and
  • Roshitha Waduge
  • High fluoride intake alters the serum fluoride level

    Serum fluoride concentration is recognized as indicator for fluoride exposure [21]. Therefore, we examined the serum fluoride levels and they were range from 0.06 to 0.07 in control and other experimental groups after 15, 30, and 60 days (Table 3). Group I had no significant difference in fluoride levels in serum after 15, 30, and 60 days compared to control groups. Though the serum fluoride concentrations were not significantly different between the control, group I, and group II of 15 days, prolonged exposure resulted statistically significant higher serum fluoride levels in group II of 30 and 60 days and the high dose-treated group III after 15, 30, and 60 days with respective to control groups (p < 0.05)............................


    Fluoride exposure impaired hepatocytes and hepatic function, which was strongly supported by the necrosis and portal inflammation histopathologically and increased serum AST, ALT, and ALP activities. Further, it has been demonstrated that there is a possibility of inducing renal damage by high fluoride levels for longer period of administration due to elevated creatinine levels. Taken together, the fact of the present early changes of liver functions following fluoride exposure before the renal lesions are appeared can be further taken into consideration by the health sector during screening of individuals in CKDu prevalent areas.


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